january-top-8-3

Posted 3:58 am,

Arthur Clarke once famously said that “Any sufficiently advanced technology is indistinguishable from magic.”  Below we’ve listed eight advanced technologies that, while not magic, represent the most cutting-edge science available today.

Read More...
Posted 6:07 am,

In the world of drug discovery, pharmaceutical companies face a very sobering statistic – more than 90% of the drugs that reach clinical testing will fail. This high failure rate is not only a major financial concern for the pharma industry, but it also negatively affects the millions of patients that are sick and desperately […]

Read More...
Posted 8:01 am,

From the desk of Chris Lipinski, PhD I’ve been thinking a lot lately about how to optimize for ligand affinity. Of course, this is a central theme of all drug discovery projects. At its core is the question of how physical and chemical relationships guide the interplay between the ligand, the protein target, and the […]

Read More...
Posted 1:40 pm,

Anyone who has taken a general laboratory class knows that the lab manual has multiple protocols that one follows in order to complete each week’s assignment. However, while the class laboratory protocol has been thoroughly tested, academic and industry protocols are often changed and improved as new information is gleaned from previous experiments. A new […]

Read More...
Posted 11:09 am,

Drug discovery, ever a challenge, can be likened to a tall structure. The upper stories rely on the stability of the floors below it, and a solid foundation is a must. No lofty heights will be reached when the base is not secure. And so, it is not a surprise that a drug discovery project […]

Read More...
Posted 10:36 am,

“Innovation” is suddenly the word on everybody’s lips.  Pfizer launched “Centers for Therapeutic Innovation”, Johnson and Johnson followed with their “Innovation Centres” and now Merck followed with their “Innovation hubs”.  In fact, it happened so fast that many of us in the dusty halls of academia are still trying to get a grip on what’s […]

Read More...
Posted 1:06 pm,

Sometimes, in tragic circumstances, a lesson can be learned and applied in unexpected ways. That appears to be the case with a rare disease that produces debilitating symptoms in children – but might also offer clues to developing a new class of antivirals. The particular disease, an extremely rare congenital disorder called CDG-IIb,  affects the […]

Read More...
Posted 9:52 am,

We have recently discussed here how crowdfunding — donations from the general public in support of a cause, idea, or invention — has caught the attention of scientists seeking financial backing in an era of tight budgets. The brave new world of crowdfunding in science raises questions that defy easy answers. What is essential to […]

Read More...
Posted 12:28 pm,

Connecting academic scientists to the global life science ecosystem Like everyone else, academic researchers are finding that funding sources are drying up and that they somehow must do more research work with less money. To do something about it, a group of Universities in Missouri and Kansas have teamed up with Assay Depot to create […]

Read More...
Posted 11:39 am,